Everything about Lipoprotein Lipase totally explained
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Lipoprotein lipase is an
enzyme that
hydrolyzes
lipids in
lipoproteins, like those found in
chylomicrons and
very low-density lipoproteins (VLDL), into three free
fatty acids and one
glycerol molecule. It requires
Apo-CII as a cofactor.
Lipoprotein lipase is specifically found in
endothelial cells lining the
capillaries.
Regulation
Insulin is known to enhance LPL synthesis in
adipocytes and its placement in the capillary endothelium.
LPL has different
isozymes in different tissues. The form that's in
adipocytes is activated by
insulin, whereas that in muscle and
myocardium is not. This helps to explain why adipose cells gain fat in a well-fed state.
Pathology
Lipoprotein lipase deficiency leads to
hypertriglyceridemia (elevated levels of
triglycerides in the bloodstream).
High-fat diets have been shown to cause tissue-specific overexpression of LPL: This has been implicated in tissue-specific
insulin resistance and consequent development of
type 2 diabetes mellitus.
Further Information
Get more info on 'Lipoprotein Lipase'.
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